Macromolecule-suppressed GABA measurements correlate more strongly with behavior than macromolecule-contaminated GABA+ measurements
نویسندگان
چکیده
منابع مشابه
Brain GABA editing without macromolecule contamination.
A new scheme is proposed to edit the 3.0 ppm GABA resonance without macromolecule (MM) contamination. Like previous difference spectroscopy approaches, the new scheme manipulates J-modulation of this signal using a selective editing pulse. The elimination of undesirable MM contribution at 3.0 ppm is obtained by applying this pulse symmetrically about the J-coupled MM resonance, at 1.7 ppm, in t...
متن کاملGABA editing at 3T with Macromolecule Suppression: MEGA-SPECIAL
Introduction. One commonly used method for in-vivo magnetic resonance spectroscopy (MRS) detection of γ-aminobutyric acid (GABA) is the MEGA-PRESS technique [1], which enables direct observation of the GABA resonance at 3.02 ppm. Unfortunately, direct quantification of GABA using MEGA-PRESS is complicated by co-editing of macromolecule (MM) signals, which also resonate at 3.02 ppm [2]. Two meth...
متن کاملGABA editing with macromolecule suppression using an improved MEGA-SPECIAL sequence.
PURPOSE The most common γ-aminobutyric-acid (GABA) editing approach, MEGA-PRESS, uses J-editing to measure GABA distinct from larger overlapping metabolites, but suffers contamination from coedited macromolecules (MMs) comprising 40 to 60% of the observed signal. MEGA-SPECIAL is an alternative method with better MM suppression, but is not widely used primarily because of its relatively poor spa...
متن کاملUsing nonequilibrium measurements to determine macromolecule free-energy differences.
S ince the advent of techniques that enable experimentalists to manipulate individual macromolecules, there has been a need for accurate estimates of free-energy changes between an initial equilibrium state and a second equilibrium state that is arrived at by a nonequilibrium manipulation. Atomic force microscopy and optical laser tweezers, often using macromolecules attached to m-sized magneti...
متن کاملIn Vivo Evaluation of the Concentration of Macromolecule Species involved in GABA Editing
C. Choi, N. J. Coupland, P. P. Bhardwaj, N. Malykhin, D. Gheorghiu, P. S. Allen Biomedical Engineering, University of Alberta, Edmonton, Alberta, Canada, Psychiatry, University of Alberta, Edmonton, Alberta, Canada INTRODUCTION γ-Aminobutyric acid (GABA) can be detected noninvasively in human brain by proton NMR spectroscopy. Spectral editing is commonly used to overcome the spectral overlap of...
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ژورنال
عنوان ژورنال: Brain Research
سال: 2018
ISSN: 0006-8993
DOI: 10.1016/j.brainres.2018.09.021